Folate (Folic acid) supplementation: a recommendation for acute, continuation and maintenance treatment of depression

Here is a dosage recommendation for supplementation with Folate/Folic acid during the treatment of depression. It’s the conclusion offered by Simon N. Young, Dept. of Psychiatry, McGill University in a 2004 review article:

What about the recommendation that 2 mg of folate be given during the acute, continuation and maintenance treatment of depression? The actual dosage may be debatable; 1 mg may suffice, particularly in countries where there is voluntary or compulsory fortification of food with folate, and the addition of a vitamin B12 supplement may be prudent, but the general principle is reasonable. With our current knowledge, the potential benefits seem to far outweigh any disadvantages.

Reference: Simon N. Young, “Folate and depression—a neglected problem” in J Psychiatry Neurosci. 2007 March; 32(2): 80–82.

For further discussion, see the NYBC entries:

Folate

B-Right (B vitamin complex)

B-12

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Florastor dosages: Saccharomyces boulardii entry on Wikipedia

We often get questions about recommended dosages of Florastor, the form of the probiotic Saccharomyces boulardii that NYBC has carried for a number of years. It was recently pointed out to us that the Wikipedia entry on this supplement includes a “Dosage Ruler” for a number of indications (conditions). See entry at:

http://en.wikipedia.org/wiki/Saccharomyces_boulardii

Higher levels of Vitamin D associated with lower risk of developing multiple sclerosis or diabetes in some groups

A New York Times piece on Vitamin D as the “Nutrient of the Decade” caught our eye. In addition to reporting on recent studies on Vitamin D’s anti-cancer properties, this article reviewed investigations linking higher Vitamin D levels to decreased risk of developing multiple sclerosis or diabetes in some populations.

Here’s a short excerpt:

The incidence of autoimmune diseases like Type 1 diabetes and multiple sclerosis has been linked to low levels of vitamin D. A study published on Dec. 20, 2006, in The Journal of the American Medical Association examined the risk of developing multiple sclerosis among more than seven million military recruits followed for up to 12 years. Among whites, but not blacks or Hispanics, the risk of developing M.S. increased with ever lower levels of vitamin D in their blood serum before age 20.

A study published in Neurology in 2004 found a 40 percent lower risk of M.S. in women who took at least 400 I.U. of vitamin D a day. Likewise, a study of a national sample of non-Hispanic whites found a 75 percent lower risk of diabetes among those with the highest blood levels of vitamin D.

For more on Vitamin D3, the supplement form mentioned in this NYT piece, see the NYBC entries:

Vitamin D 3 1000IU

and

Vitamin D3 400IU