PharmaNAC (effervescent n-acteylcysteine) and MAC-Pack (K-Pax alternative)

A few words about PharmaNAC, an effervescent NAC (n-acetylcysteine) that the New York Buyers’ Club has been supplying in the past year. This form of NAC has proven especially useful to people with respiratory conditions like chronic bronchitis. And we were interested to read recently of a person with cystic fibrosis reporting on her use of PharmaNAC.

NAC in various forms has been researched and used more widely in Europe than in the US, although some influential work on this supplement for people with HIV was conducted at Stanford back in the 1990s, and helped lead, for example, to the inclusion of NAC in K-Pax, a multivitamin antioxidant combination that showed significant enough benefit to be added to state government-financed formularies for people with HIV.

NYBC originally imported a German effervescent NAC called ACC Akut (Hexal), but we were delighted when a North American supplier began to offer the very similar PharmaNAC, which we have stocked for the past year. (PharmaNAC is actually a higher dose of NAC per tab–900mg–than ACC Akut’s 600mg, though we have been able to keep the price about the same due to lower shipping costs.)

NYBC’s mission as a nonprofit buyers’ co-op also motivated us to devise a low-cost alternative to K-Pax for those who don’t have access to subsidized versions of this product. The NYBC MAC-Pack provides a close equivalent to K-Pax, but the cost has been brought down to less than half that of K-Pax.

Note: it’s also possible to order non-effervescent NAC and ThiolNAC separately:

NAC 500mg/90 tabs

ThiolNAC (500mg NAC and 200mg alpha lipoic acid/90 tabs)


Regular supplementation with NAC (N-acetylcysteine) can help control chronic bronchitis

This study, published in 2000, looked back at two decades of research and found that regular supplementation with NAC was associated with better control of chronic bronchopulmonary disease (such as chronic bronchitis). Perhaps a good study to keep in mind, since we are approaching the season in North America when respiratory tract problems can become more acute. 

Reference: Grandjean EM, Berthet P, Ruffmann R, Leuenberger P,
“Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials,” in Clinical Therapeutics 2000 Feb;22(2):209-21.

Additional note on NAC: it’s an antidote to acetaminophen (Tylenol is the best-known brand name in the US) and can counter liver toxicity associated with  acetaminophen use. Widely used for this purpose in Europe, where NAC and acetaminophen are frequently combined.

See NYBC’s description of

NAC 500mg


PharmaNAC–Effervescent NAC 900mg

PharmaNAC is certified compliant to the standards of the European Pharmacopoeia and USP; it’s a format that’s easy to take and similar to the ACC Akut effervescent NAC (Hexal) formerly imported by NYBC.