Mayo Clinic recommendations: cholesterol-lowering supplements

The Mayo Clinic has a post, updated in 2012, on the topic of “Cholesterol-lowering supplements: Lower your numbers without prescription medication.” As always, we advise you to check with your healthcare provider before starting to use any of these for cholesterol management.

Most of these suggestions have been in the New York Buyers’ Club repertory for quite a while, but we are happy to repeat them here:

Fish oil (omega-3 fatty acids): can lower triglycerides

Green tea: some research on its cholesterol-lowering capacity; epidemiologic evidence suggests that green tea may lower stroke and cardiovascular disease risk. There are several choices for green tea supplements: see Green Tea; Green Tea Decaffeinated; and Green Tea Organic.

Plant sterols: see Cardio Edge for a supplement featuring plant sterols in a formula designed to support healthy cholesterol levels

Garlic extracts: contact NYBC for information on allicin, a garlic extract that has been studied for cardiovascular health

The Mayo Clinic guide also mentions grains, including oat bran and flaxseed, which can lower cholesterol.

Last, the guide discusses red yeast rice, a supplement that can lower LDL cholesterol. Note the caution that some forms of red yeast rice may contain a naturally occurring form of the prescription medication lovastatin. Lovastatin in the supplement may present some dangers to the user, because there is no way to know the quantity or quality of this prescription medication equivalent. For that reason, it is especially important to consult with your healthcare provider and monitor your usage of this supplement.

See the Mayo Clinic guide at

Mayo Clinic: Cholesterol-lowering supplements: Lower your numbers without prescription medication

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Healthy cholesterol levels the botanical way

We’ve long known about certain supplements like niacin, pantethine, omega-3 fatty acids that can have an effect on cholesterol levels. In recent years, research attention has also focused on “plant sterols” and other botanical substances that can provide help in supporting healthy cholesterol levels.

Responding to this emerging science, supplement suppliers have devised some combination supplements. Among them is Douglas Lab’s Cardio-Edge, which includes: plant sterols (phytosterols) from soy; Sytrinol (a proprietary extract obtained from citrus and palm fruits); and pomegranate extract.

Here’s a little more detail on the product:

Cardio-Edge is designed to help maintain cardiovascular health and support healthy cholesterol levels. Sytrinol is intended to have the following effects, some of which you can monitor with routine bloodwork to assess its effect for you. These include:
1) Decrease apoprotein B, needed for LDL synthesis
2) Decrease action of an enzyme in the liver that makes triglycerides
3) Inhibit HMG-CoA reductase in the liver

Patented combination of citrus PMFs and alpha, delta and gamma tocotrienols derived from palm fruit (U.S. patents #6,251,400, and #6,239,114). Palm tocotrienols have been shown to inhibit HMG CoA reductase, the enzyme responsible for regulating cholesterol synthesis in the liver. Clinical studies in both animals and humans support Sytrinol’s role in reducing total and LDL-cholesterol as well as triglycerides.

Plant Sterols
Blood cholesterol is derived from the diet and synthesized in the liver. Sterols work by reducing the absorption of both forms of cholesterol – Sterols compete with cholesterol for absorption. Sterols and sterol esters can now be found in many foods including orange juice, rice drink, and margarine.

Pomegranate
Recent science has been focusing on the cardioprotective aspects of pomegranate. These brightly colored fruits contains numerous cornpounds known for their antioxidant capabilities, induding anthocyanidins, catechins, tannis, and gallic and ellagic acids. Research has shown that supplementation with pomegranate juice can decrease macrophage lipid accumulation, and cellular cholesterol accumulation in mice. Recently, research in humans has confirmed a beneficial effect of consuming pomegranate juice on parameters such as LDL oxidation, blood pressure, and blood vessel health.

In human clinical studies involving hypercholesterolemic subjects, no side effects were observed and four weeks of supplementing with a daily dose of 300 mg of Sytrinol.

See further information on recommended dosing on the NYBC website:

http://nybcsecure.org/product_info.php?products_id=284

Niacin and cholesterol control: when d4T/stavudine (Zerit) and protease inhibitors worsen cholesterol problems in people with HIV

This note appeared in the Winter 2007 issue of the NYBC newsletter The Supplement, so we’re citing it to add to our ongoing discussion  of dietary supplement strategies for cholesterol control.

Vitamin B3 aka Niacin has long been recognized as effective in managing high cholesterol (high LDL level), and has the added advantage of improving levels of HDL (“good cholesterol”), which is often low in HIV infection (treated or not). The problem: high-dose Niacin can cause unpleasant “flushing and itching.” One approach is to increase the dose slowly to about 1.5 to 3 grams a day over a period of a couple of weeks. This is an alternative that people on antivirals may wish to try, working with their physicians, in order to manage cholesterol problems that can be worsened by certain antivirals – notably d4T/stavudine (Zerit) – and protease inhibitors.