Grapeseed may reduce risk of prostate cancer

The well-known Fred Hutchinson Cancer Research Center in Seattle Washington is the source for a large recent survey on supplements for cancer prevention. (We’ve already discussed on this blog their 2010 survey highlighting an association between fish oil supplements and lower risk of breast cancer.) This new research, published in May 2011, focuses on grapeseed supplements and reduced risk of prostate cancer.

More than 35,000 male participants from 50 to 76 years old were recruited for a detailed baseline questionnaire in 2000-2002. Upon follow up five years later, 1,602 prostate cancers had been registered among study participants. Any use of grapeseed supplements among the 35,000 participants was associated with a 41% reduced risk of total prostate cancer. There were no associations between prostate cancer risk and use of chondroitin, coenzyme Q10, fish oil, garlic, ginkgo biloba, ginseng, glucosamine, or saw palmetto.

This large survey study follows after a number of preliminary lab studies of the anti-cancer effects of grapeseed. See the Memorial Sloan/Kettering website for more information: http://www.mskcc.org/mskcc/html/69243.cfm

NYBC stocks Grapeseed Extract from Jarrow.

Reference: Brasky TM, Kristal AR, Navarro SL, Lampe JW, Peters U, Patterson RE, White E. Specialty Supplements and Prostate Cancer Risk in the VITamins And Lifestyle (VITAL) Cohort. Nutr Cancer. 2011 May;63(4):573-82.

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Antioxidant Optimizer: broad spectrum antioxidant formula

NYBC now stocks Antioxidant Optimizer from Jarrow Formulas, a broad spectrum antioxidant supplement that provides a blend of water and fat soluble antioxidants ( meaning they are widely absorbed in the body), including:

Lutein and lycopene, which protect the eyes, cardiovascular system, breast, cervical, and other tissues and organs;

and

Green tea extract, olive fruit extract, grape seed extract, and milk thistle, which support liver health and cardiovascular system health.

For more details, see the NYBC entry:

Antioxidant Optimizer

Yes, you’ll also notice that NYBC’s nonprofit co-op price for this product is very reasonable!

Resveratrol and Resveratrol Synergy

Recent well-regarded research has provided evidence that resveratrol can decrease the kinds of inflammation associated with heart disease, and can improve motor coordination, reduce cataract formation and preserve bone mineral density in aging laboratory animals. (See, for example, the report on an NIH-funded study published in the journal Cell Metabolism in August 2008.) In short, resveratrol may counteract many typical types of age-related deterioration in the body. As the researchers have noted, these anti-aging effects mimic the effect of drastically reducing (by 30-50%) food intake—but without requiring such a near-starvation diet.

That’s the recent research background on resveratrol. We’ll also note that resveratrol as a compound with potential health benefits was originally isolated as a component of red wine. Of course, in supplement form resveratrol can provide its health benefits without requiring the user to drink alcohol. That’s a practical advantage to supplementation that can’t be ignored.

Note that in addition to “Resveratrol,” NYBC also offers a compound supplement from Jarrow called “Resveratrol Synergy.” This product includes includes resveratrol, grape seed extract, and green tea extract. Grape seed extract has been studied mostly for cardiovascular support, while green tea has recently accumulated some interesting research supporting its anti-cancer and anti-aging effects.

To read more about these two supplements, see the NYBC entries:

Resveratrol: http://nybcsecure.org/product_info.php?cPath=50&products_id=330

and

Resveratrol Synergy: http://nybcsecure.org/product_info.php?cPath=50&products_id=245

Grape Seed Extract for Colon Cancer Prevention

NCCAM (NATIONAL CENTER FOR COMPLEMENTARY AND ALTERNATIVE MEDICINE) is sponsoring a 5-year study of grape seed extract for prevention of colon cancer. The study, being conducted at the University of Colorado – Denver, is based on a number of promising lab studies of this botanical substance.

Here’s an excerpt from the abstract of this study:

Colon Cancer Prevention by Grape Seed Extract

Colorectal cancer (CRC) is the second most common cause of cancer deaths in humans, and about 5% of the US population will develop CRC in their life times. Overall, CRC growth, progression and metastasis involve a gradual accumulation of genetic and epigenetic changes over a period of years. One approach to control CRC growth and metastasis could be its prevention by phytochemicals present in diet and those consumed as dietary supplement, which inhibit one or more events of neoplastic stages and reduce overall cancer risk. Grape seed extract (GSE) is a widely consumed dietary supplement in the United States for its several health benefits, and is a rich source of standardized phytochemicals known as proanthocyanidins. […] We anticipate that proposed studies will identify GSE as a mechanism-based dietary supplement agent for the prevention of CRC, and will establish its in vivo efficacy in pre-clinical CRC models. As a practical and translational approach, the long- range goal of these studies would be to define and establish the usefulness of GSE for the prevention and intervention of human CRC.

See the NYBC product:

Grape Seed Extract

Related References:
Kundu JK, Surh YJ (Oct 2008). “Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives”. Cancer Lett. 269 (2): 243–61.
Katiyar SK (Jun 2008). “Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system”. Mol Nutr Food Res. 52 Suppl 1: S71–6.

Reviewing “Resveratrol Synergy” from Jarrow

Jarrow Formula’s supplement “Resveratrol Synergy” is a combination of several plant-derived nutrients that have been intensively researched in recent years, including resveratrol (the famous component of red wine), grape seed extract, and green tea. This phytonutrient blend provides the body with antioxidants, anthocyanins, polyphenols and catechins, which are generally acknowledged to support cardiovascular health, as the Jarrow label states.

But there is more to these plant-derived nutrients, as you may know from hearing news reports, especially about resveratrol. Typically found in the skin of red grapes and in red wine, resveratrol has been the subject of scientific investigations suggesting that it possesses unique life-extending and anti-aging properties. Some of the recent studies draw a causal connection between gene protection and high levels of resveratrol consumption; other research has focused on how resveratrol may switch on a particular “survival gene” that offers a whole host of health benefits, from cardiovascular support to diabetes prevention.

As far as product quality goes, NYBC noted that a recent Consumer Labs report found that the ingredients matched the label claim–one good measure of integrity for “Resveratrol Synergy.”

For more information, see the NYBC entry:

Resveratrol Synergy