“Natural mood enhancer”: Trimethylglycine (TMG)

Trimethylglycine (TMG for short) has been described as a “natural mood enhancer” by Dr Hyla Cass, a practicing physician who’s long advocated for more integrative approaches to mood disorders. That’s because TMG provides the raw materials that the body can use to manufacture S-adenosylmethionine (SAMe). SAMe, as you might know from reading other entries on this Blog, is a well-researched supplement with antidepressant effects comparable in some studies to prescription antidepressants. TMG is also a lot cheaper than SAMe! Cautions: Dr. Cass stresses the importance of being under a doctor’s supervision if using TMG while taking prescription antidepressants, since an excessive build up of the neurotransmitter serotonin is possible. Also note cautions about TMG’s potential role in bacterial growth, which has led to the recommendation not to use during an infection.

For more information on TMG, including dosage recommendations, see



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