Grape Seed Extract for Colon Cancer Prevention

NCCAM (NATIONAL CENTER FOR COMPLEMENTARY AND ALTERNATIVE MEDICINE) is sponsoring a 5-year study of grape seed extract for prevention of colon cancer. The study, being conducted at the University of Colorado – Denver, is based on a number of promising lab studies of this botanical substance.

Here’s an excerpt from the abstract of this study:

Colon Cancer Prevention by Grape Seed Extract

Colorectal cancer (CRC) is the second most common cause of cancer deaths in humans, and about 5% of the US population will develop CRC in their life times. Overall, CRC growth, progression and metastasis involve a gradual accumulation of genetic and epigenetic changes over a period of years. One approach to control CRC growth and metastasis could be its prevention by phytochemicals present in diet and those consumed as dietary supplement, which inhibit one or more events of neoplastic stages and reduce overall cancer risk. Grape seed extract (GSE) is a widely consumed dietary supplement in the United States for its several health benefits, and is a rich source of standardized phytochemicals known as proanthocyanidins. […] We anticipate that proposed studies will identify GSE as a mechanism-based dietary supplement agent for the prevention of CRC, and will establish its in vivo efficacy in pre-clinical CRC models. As a practical and translational approach, the long- range goal of these studies would be to define and establish the usefulness of GSE for the prevention and intervention of human CRC.

See the NYBC product:

Grape Seed Extract

Related References:
Kundu JK, Surh YJ (Oct 2008). “Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives”. Cancer Lett. 269 (2): 243–61.
Katiyar SK (Jun 2008). “Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system”. Mol Nutr Food Res. 52 Suppl 1: S71–6.


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