Cardio-Edge (Douglas Labs): a plant sterol, Sytrinol and pomegranate-based supplement to maintain cardiovascular health and support healthy cholesterol levels

The NYBC co-op has recently added this item in the category of cholesterol management. For a while now we have been interested in the potential of plant sterols for maintaining healthy cholesterol levels, and we noted that our well-regarded supplier Douglas had formulated a supplement that incorporates both plant sterols and two other plant-based components that show a potential benefit in cholesterol management.

Cardio-Edge (Douglas Labs). Cardio-Edge is designed to help maintain cardiovascular health and support healthy cholesterol levels. Its significant components are:

Plant sterols (phytosterols) from soy – 200 mg
Sytrinol – 75 mg
Standardized pomegranate extract (fruit; standardized to 40% ellagic acid) – 25 mg

Plant Sterols
Blood cholesterol is derived from the diet and synthesized in the liver. Sterols work by reducing the absorption of both forms of cholesterol–sterols compete with cholesterol for absorption. Sterols and sterol esters can now be found in many foods including orange juice, rice drink, and margarine.

This is a proprietary extract of polymethoxylated flavones and tocotrienols from citrus and palm fruits. Sytrinol is intended to have the following effects, some of which you can monitor with routine bloodwork to assess its effect for you. These include:

1) Decrease apoprotein B, needed for LDL synthesis
2) Decrease action of an enzyme in the liver that makes triglycerides
3) Inhibit HMG-CoA reductase in the liver

Sytrinol includes a patented combination of citrus PMFs and alpha, delta and gamma tocotrienols derived from palm fruit. Palm tocotrienols have been shown to inhibit HMG CoA reductase, the enzyme responsible for regulating cholesterol synthesis in the liver. Clinical studies in both animals and humans support Sytrinol’s role in reducing total and LDL-cholesterol as well as triglycerides.

In human clinical studies involving hypercholesterolemic subjects, no side effects were observed with four weeks of supplementing with a daily dose of 300 mg of Sytrinol.

Recent science has been focusing on the cardioprotective aspects of pomegranate. This brightly colored fruit contains numerous cornpounds known for their antioxidant capabilities, including anthocyanidins, catechins, tannins, and gallic and ellagic acids. Research has shown that supplementation with pomegranate juice can decrease macrophage lipid accumulation and cellular cholesterol accumulation in mice. Recently, research in humans has confirmed a beneficial effect of consuming pomegranate juice on parameters such as LDL oxidation, blood pressure, and blood vessel health.

Please let us know if you have questions or comments about this new item on the NYBC list–emails are welcomed at


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