Coenzyme Q 10 reverses diastolic dysfunction related to taking statins
June 23, 2007
Here’s a report from 2004 on CoQ10 and how it may benefit people taking statins:
NEW YORK (Reuters Health) - Findings from a small study suggest that statin therapy can impair left ventricular diastolic function, but that coenzyme Q10 supplementation can reverse this dysfunction. “For more than a decade, there has been a suggestion of impairment of diastolic function after the administration of statins, and our findings suggest that this may be a common event and potentially a precursor to symptoms associated with ventricular dysfunction,” lead author Dr. Marc Silver, from Advocate Christ Medical Center in Oak Lawn, Illinois, and colleagues note. As such, routine coenzyme Q10 use may be beneficial, they add.The findings, which appear in the American Journal of Cardiology for November 15th, are based on a study of 14 asymptomatic patients who were treated with atorvastatin at a dose of 20 mg/day for 3 to 6 months.Doppler echocardiography was used to assess left ventricular diastolic function before and after atorvastatin therapy. Patients who showed worsening of diastolic function were offered treatment with coenzyme Q10 while continuing atorvastatin therapy.
During follow-up, 10 of the patients showed worsening of at least one marker of diastolic function, the authors note. Nine of these patients elected to take coenzyme Q10 capsules and eight showed reversal of at least one diastolic abnormality.
Although statins are thought to reduce coenzyme Q10 levels, not all of the patients in the current study showed significant reductions. Moreover, there was no evidence that baseline levels predicted diastolic dysfunction. Therefore, the authors support the routine administration of coenzyme Q10 capsules when statins are given.
The study was supported, in part, by Kaneka Corporation, Osaka, Japan, which markets coenzyme Q10 under the name KanekaQ10.
Am J Cardiol 2004;94:1306-1309.
For additional CoQ 10 information, see the NYBC Supplement Fact Sheets.
NYBC Product Info Sheets:
Entry Filed under: Coenzyme Q10. Tags: CoQ 10, diastolic dysfunction, statins.
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